Depends on the build, but usually:
- F1-F5 for long duration buffs
- Z-X-A for my main skills
- Q for most used utility skill (windform/edyrem/purify)
- S/C for short duration buffs (rapture/vindicate) and panic skills (pagan rites/sacred armor/spellbind)
- D for town portal, V for teleport, Space for move only, Caps Lock for swap weapons, the rest are for other skills if needed. If I'm playing barb I also have 2 most used stances bound to mouse wheel