Hi,
Are you playing on realm or Single Player? If you are playing Single Player, then the easiest way to mule things would be to use PlugY or download D2SE Mod Manager and enable PlugY when you select whatever mod you wish to play.
If you are playing on Realm, you can use Sandbox or enable multiple launches of LOD through PlugY config in your D2SE folder to mule for other characters on Realm.
It is recommended to mule Tiered Uniques (which are the ones you're finding) since they can be very useful for later when you trying to gear up your character and your hireling, as well as, saving them for other characters. Usually doing Griswold Runs involve farming Tristram to kill Griswold for Gift Boxes which when transmuted in the cube produce 3 TU's usually designed for you class. Each class has different results so using mules to transfer Gift Boxes over would be recommended but not necessary. You don't have to farm Griswold at all since none of the TU's are absolutely necessary, but they are very useful. If you don't want to mule characters or don't have any immediate plans for your TU's then simply disenchant them into Arcane Shards. 5 Arcane Shards -> Arcane Crystal and with certain recipes you'll be able to upgrade or up-tier the TU's you've been using. There are various other uses for Arcane Crystals but assuming your just starting off, you don't need to worry about them. All the information about Arcane Crystals and Arcane Shards can be found in the Docs under Items->Cube Recipes->Disenchanting.
Crafting Points are not necessary to use the Catalyst of Disenchanting, Catalyst of Destruction, and the Catalyst of Learning. However, you will need Crafting points to craft Jewels with certain prefixes/suffixes later with the Oil of Craft.
Yes, the only thing Pearls of Wisdom are just helpful tips and if you cube 1 by itself, you can cycle through all the information. All the information found on the Pearls of Wisdom can be found in the Docs.