Fend's point is that it gives you 20% physical resist with 100% uptime because it's actually 20 second cooldown and 30 second duration.
Curare poison build and Paragon dex stack build both work, decent farming but not great at boss killing.
Curare SSF gear:
Lethal Huntress
Lethal Huntress
Amazon Spears
'IstVenVen'
Runeword Level: 100
5% Chance to cast level 12 Javelin Nova on Kill
+(4 to 5) to Amazon Skill Levels
50% Attack Speed
250% Bonus to Attack Rating
-(30 to 35)% to Enemy Poison Resistance
+(150 to 200) to Dexterity
+(250 to 400) to Life
Physical Resist 10%
+(80 to 100) Life on Melee Attack
(20 to 25)% Magic Find
Amanita
Amanita
Helms
'VenAmn'
Runeword Level: 100
3% Chance to cast level 1 Time Wave on Melee Attack
+(200 to 300) to Attack Rating
-(21 to 25)% to Enemy Poison Resistance
+(2 to 5) to Amatoxin
(3 to 5)% Chance of Crushing Blow
Attacker Flees after Striking 20%
+(115 to 143)% Enhanced Defense
+(30 to 50) to Vitality
Poison Resist +25%
Mithridatism
Mithridatism
Gloves
'VenOhm'
Runeword Level: 100
Gain 20% of your Poison Resistance as Poison Length Reduction
+1 to All Skills
25% Hit Recovery
Adds 300-400 Poison Damage over 2 seconds
-(7 to 10)% to Enemy Poison Resistance
+(141 to 171)% Enhanced Defense
+10 to all Attributes
Poison Resist +25%
Angel of Death
Angel of Death
Amulet
Required Level: 90
Item Level: 123
2% Chance to cast level 33 Punisher Bolt on Striking
+(0 to 2) to All Skills
+(11 to 30)% to Poison Spell Damage
-(6 to 15)% to Enemy Poison Resistance
Astrogha's Moon
(Wyrd Set)
, rare rings with +1 skills and poison pierce
Curare ideal setup:
Serenthia's Scorn
Serenthia's Scorn
Maiden Pike (Sacred)
Two-Hand Damage: (124 - 167) to (224 - 302)
(Amazon Only)
Required Level: 100
Required Strength: 350
Required Dexterity: 590
Item Level: 105
Dexterity Damage Bonus: (0.15 per Dexterity)%
Amazing Grace
Gematria
(Bonus per Socketed Great/Elemental Runes)
+1 to All Skills
+2.5% Physical Resist
+30 Life After Each Kill
-10% to Enemy Poison Resistance
1% Chance to cast level 50 Rotting Flesh on Striking
+1000 Poison Damage over 2 seconds
+(100 to 170)% Enhanced Damage
+(1000 to 2000) Defense
+(50 to 100) to all Attributes
+(400 to 750) to Life
Socketed (6)
, full
Astrogha's Moon
Astrogha's Moon
(Wyrd Set)
Darkling
Viper Skin
Angel of Death
Set Bonus with 2 or more set items:
Maximum Poison Resist +2%
Poison Resist +75%
Set Bonus with complete set:
-25% to Enemy Poison Resistance
+23 to Amatoxin
Slow Target 5%
, maybe a tiny bit more pierce to hit 135/145 for farming, whatever you want for the rest because at max pierce, 1 item poison, and Amatoxin your poison doesn't get any better except for + skills.
Dex stacking build does whatever the hell it is that dex stackers do.
Paragon gear suggestions (don't take this as an actual build, I haven't played it yet): Big phys damage spear, abandon crafted armor,
Royal Circlet
Royal Circlet
Tiara (Sacred)
Defense: (1740 - 1957) to (1968 - 2214)
Required Level: 100
Required Dexterity: 392
Item Level: 105
+2 to All Skills
+50% Damage to Demons
+50% Damage to Undead
+(140 to 170)% Enhanced Defense
(21 to 25)% to All Attributes
Elemental Resists +(25 to 30)%
Physical Resist 5%
(21 to 25)% Magic Find
Socketed (4)
or
Witchhunter's Hood
Witchhunter's Hood
Cap (Sacred)
Defense: (2136 - 2611) to (2161 - 2642)
Required Level: 90
Required Strength: 250
Item Level: 1
+(80 to 120)% Enhanced Defense
10% to Strength
10% to Dexterity
Maximum Elemental Resists +2%
Elemental Resists +(31 to 40)%
Physical Resist 5%
(16 to 20)% Bonus to Defense
Requirements -50%
Socketed (4)
Witchhunter's Attire
(Assassin Claw Set)
as needed,
Black Void
Black Void
Heavy Belt (Sacred)
Defense: (3060 - 3442) to (3304 - 3717)
Required Level: 100
Required Strength: 625
Item Level: 120
20% Attack Speed
Adds 10-15 Damage
(10 to 15)% Life stolen per Hit
Slow Target 10%
+(140 to 170)% Enhanced Defense
10% to Strength
10% to Dexterity
Target Takes Additional Damage of (25 to 50)
30% Magic Find
Socketed (2)
,
Zealot Rush
Zealot Rush
Light Plated Boots (4)
Defense: (67 - 78) to (102 - 119)
Required Level: 6
Required Strength: 31
Item Level: 10
5% Attack Speed
(10 to 40)% Movement Speed
(11 to 25)% Bonus to Attack Rating
+(21 to 40)% Enhanced Defense
(3 to 5)% to Dexterity
1% Reanimate as: Random Monster
Socketed (1)
Defense: (248 - 281) to (338 - 384)
Required Level: 24
Required Strength: 62
Item Level: 36
10% Attack Speed
(10 to 40)% Movement Speed
(41 to 55)% Bonus to Attack Rating
+(41 to 60)% Enhanced Defense
(9 to 11)% to Dexterity
2% Reanimate as: Random Monster
Socketed (2)
Defense: (613 - 685) to (817 - 914)
Required Level: 41
Required Strength: 218
Item Level: 51
20% Attack Speed
(10 to 40)% Movement Speed
(71 to 85)% Bonus to Attack Rating
+(61 to 80)% Enhanced Defense
(15 to 17)% to Dexterity
3% Reanimate as: Random Monster
Socketed (3)
Defense: (944 - 1044) to (1247 - 1378)
Required Level: 50
Required Strength: 436
Item Level: 85
30% Attack Speed
(10 to 40)% Movement Speed
(86 to 100)% Bonus to Attack Rating
+(81 to 100)% Enhanced Defense
(18 to 20)% to Dexterity
4% Reanimate as: Random Monster
Socketed (4)
->
Akarat's Trek
Akarat's Trek
Light Plated Boots (Sacred)
Defense: (1960 - 2352) to (2170 - 2604)
Required Level: 100
Required Strength: 625
Item Level: 120
2% Chance to cast level 30 Hammertime on Melee Attack
2% Chance to cast level 30 Thunder Wave on Melee Attack
2% Chance to cast level 30 Thunder Hammer Nova on Melee Attack
(10 to 40)% Movement Speed
+(15 to 20) to Charged Strike
Weapon Physical Damage +(60 to 90)%
+(150 to 200)% Enhanced Defense
10% to All Attributes
+10 to Light Radius
Socketed (4)
,
Marksman's Eye
Marksman's Eye
Mystic Orb
Right-Click to Apply
5% Attack Speed
+3 to Minimum Damage
10% Bonus to Attack Rating
2% to Dexterity
+10 Required Level
, as many perfect amethysts as you can get away with. Encino supposedly does like 30k magic damage per pounce with similar or better gear than this.