You get free nephalem spirit, you have no shield, so obviously you use runes for runemaster.
Attack speed, you have main and offhand in speedcalc put correct WSM of each in correct box (5 and -5), select dual wield 2x slash animation.
Use axe as main hand because it has better damage, always make sure on your character he uses axe as his hitting weapon (look at model of character not inventory).
For this id go either 5pt sword spiral for farming, or 5pt gaze for more all round/bossing, and then getting like creepy gloves with 15 pierce (depending on what you go for cold or lightning), and creepy belt with up to 10 (i think) pierce too. Both these slots can roll rare pierce mod, outside of shrine, so with creepy you can get 15 gloves and 10 belt, or if you use sacred (cold) or ornate (lightning), then gloves go to 15+8+8 = 31 pierce and belt 10+8+8=26, but you end up with kind of caster pierces no %stats. Up to you, vs boss more pierce will be better.
For pure boss dps, you can max iceburst for extra 60 pierce on top, set also has some cold pierce on it.
You can also go eagle stance, get defense from wolves and maxed spirit guide, go like 50:50 str/vit, get 20-25k hp. Your neph damage goes down if you dont go full str, but there is extra benifit then for eagle stance. You need to stack way more ias for this because eagle has -30 skill ias, but its doable to reach 6fpa breakpoint for dual wield. Then belt truce rw for 10dr, gloves set with 10% dr (gelebs greed). You will heal all the time, you gain nice lifesteal. With some 1% DR on armors, TA trophy and those 2 armor slots you end up with about 30% DR. Problem is defense is little unreliable as if your wolves get blocked you may drop with defense to 200kish, otherwise your defense should be on pair with bear. Its pretty comfortable to play with this stance because of the constant heal, infinite mana regen, pretty nice for farming.