Mystic orbs: Weapon: %enhanced damage, %AR, life leech; Armors: %enhanced defense, total character defense, stats
Probably more optimal to replace the Enhanced Defense / TCD with Max Dam & MF orbs. +10 Max Damage gets scaled to >200 already at level 105 / with TUs / 0 charms and we reach fairly low "% chance to be hit" once we get each socket filled with a rune (even with only 1 level in Wolven Guide). I suggest MF since this seems to be an early- to midgame farming build intended to transition into something more endgame viable sooner or later. I would go to 200% ED on body armor and shield (if you're going 1-handed) and otherwise skip the %ED/TCD. Or at least keep an eye on when you start reaching "high enough" levels of armor and switch to max dmg MOs at that point.
Another suggestion: Start investing points into Earth Quake after you max Wolf Stance & Moutain King (maybe even before MK). Here are 2 screeenshots, first with maxed EQ and one with maxed Wolven Guide (Balanced Axe TU + Invictus):
You can see I gain 200min / 400max Damage with EQ max. EQ also maxes out at 20 so you have some more points freed up. The defense drops looks big BUT I only had 1/2 of my sockets filled with runes at this point, otherwise I would have been at 5% CTBH with or without Wolven Guide. You will need 1-2 Mana On Meele Attack MO since EQ costs ~28 Mana when maxed out (keeps going up a bit as you gain +Skills from gear/charms). Maybe also 1 point in Meditation (don't think it's needed though).
Here another 2 screenshots, this time with Labrys TU, first one is with EQ max again, second Wolven Guide max :
Going 2-handed you gain 400-700 Damage with EQ max. Without the shield the armor difference might actually matter but maybe not since i'm still missing 10 runes, so the relative difference would be much lower if fully socketed. Right now I go from 13% CTBH to 6% with maxed Wolven Guide. Roughly doubling the chance to be hit is not nothing, but again, would be lower with full runes. And the damage gained is quite decend as well.
- Against bosses you lose some SoR damage with EQ max so in the end you're DPS probably remains around equal. The damage increase should be most noticeable while farming.
- You lose some FCR so casting becomes a tad slower.