Just wanted to post about something I tried, hopefully this will be found useful.
When I was playing through with Wolf Druid, everything was going great until around the lvl 90 range in late nightmare. I felt like the damage and defense fell off drastically, and there was really no gear improvements to be made until I could start getting set items (I was in T4 everything per the guide). I've heard that a lot of people go through the same hurdle around this point, and the guide even mentions it.
I had a sacred crystal sword laying around, so I decided to mess around and try a dexterity variant. Best decision I ever made. I crafted the two items shown below, the sword is nothing special, got kinda lucky with the shield though. These were the only gear changes I made from the guide, and for sockets I switched to amethysts and IO runes for tons of dex. I also moved the points from Werewolf Form into Twisted Claw for better bossing skill. It was like a new-found strength... my damage almost doubled and I gained 35% block chance on top of all the avoid the Wolf tree offers. The build feels leaps ahead of what it was pre-switch, and I just self-tanked The Butcher and trucked through The Infernal Machine, both as soon as I dinged 105.