I have no advice to give, because I will never attempt him.
I like Median for leveling and low ubers, to build a crapton of characters. I have 3 assassins, 4 amazons, 2 sorceress, etc... I rarely farm signets: that's only necessary if you want to beat every single uber. I never farm until level 120 (usually starting Destruction at level 110-115). By playing like this, the game is always "new and fun". It never asks you for 6 hours consecutive gametime just to beat one particular zone. And you really don't need the late uber charms to have fun.
You could consider playing a bit more like this. It definitely delivers in terms of fun and it's both accessible (play when you want, as much as you want), fair (you can always do everything) and challenging (as long as you don't play *THE* overpowered lvling specs. Leveling in melee will always provide some challenge for example).
Late ubers are all about cheesing them. They do provide interesting challenges for people who like to farm a lot, but they all essentially boils down to:
-: reach a stat lvl
-: have some particular skillset
-: have the exact strategy required
They are well designed. But they are not designed for every characters, skillset, reasonably obtainable gear, person, etc... If you feel they are not worth your time, then they are probably not worth your time. You still have a lot of game to enjoy.
As a side note, I wonder what Laz is thinking seeing all these talks about how to kill him

Same for MarcoNecro ^^'