I have performance issues with d3d and lose the cool lighting effects with ddraw. With glide I get the best of both worlds - the visuals and the performance.
Also, there is no point in doing Ureh or Astro on Hatred, so don't "come back 90 levels later", just skip them

these are high-end uberquests so just wait until you have a strong character with good gear and a better understanding of this mod and try them on Destruction(unless you want to practice first, then doing them on hatred is probably fine).