On boss, like Azmodan, Neutraldin may use Crafted gloves with Desintegrate.
1) Run next to the boss
2) Cast Desintegrate
3) Run away, wait cooldown and upcast Sacred Armor & Demiurge
4) go to step 1
3a) If do fast, may do 2 run before upcast. But in that case sometime I'm die. After 3-7 die i giveup 2 run in 1 upcast) Be cool if duration Sacred Armor & Demiurge up to 24-27 sec.
for me it seams like faster/easiest/safety do boss, then Vessel)