What Gekko said - we are a full dex build. ITD is useless for us because we already have great attack rating. BTW familliar is no big deal, it's the other mods on that bow that make it top notch. However Chasmstriker does give it a run for its money and might even be better if you are running asgardsreia + natasha's legacy.
As for sockets - we are using paragon, so all non-runeword sockets should be filled with gems. For the bow this means 6 perfect rainbow stones. For the armors if you are just entering destruction and have no charms - use the +max elemental resistance gems: onyx, bloodstone, amber & turquoise. Later with azmodan charm & kabraxis you will switch those out for perfect amethists.
BTW if you have full pantheon then you have nothing to worry about breakpoints. The set already gives -75 enemy allres, which together with sunstone of the elements & sunless bird charm caps you out. It also gives 50 attack speed which maxes fpa with ecstatic frenzy and 3-5 points in wild and free take care of your FHR.