depends on how much damage does your 1h have (what procs? ) and how many benefits you get from using a shield . for example
Headsman
Headsman
Hand Axe (Sacred)
One-Hand Damage: (316 - 331) to (420 - 435)
Required Level: 100
Required Strength: 376
Item Level: 120
Strength Damage Bonus: (0.11 per Strength)%
25% Chance to cast level 13 Shockwave on Melee Attack
25% Attack Speed
Adds 250-350 Damage
150% Bonus to Attack Rating
+(80 to 120)% Enhanced Damage
30% Gold Find
25% Magic Find
+(3 to 5) to Light Radius
Socketed (3)
is as good as a 2h in end game in therms of physical damage
in the early game you can skipp the extra defence you got from the shield and go for higher damage (2h) instead . it's not like you get hit very often anyway + you got retaliate to perma-push back your opponents if needed