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In Resurgence we have expanded upon the idea of specialized skill trees. To that end we have unique charms which empower certain builds and playstyles. To begin the path to gaining a subclass you must kill Baal in Hell. He will drop a blank subclass charm for a class at random.
Once obtaining your class-specific base Nephalem's Valor charm, you must sacrifice one out of three of the following relevant Uniques in order to ascend to new powers.
Barbarian
Slayer: Carnage Heart, Deathspade, Rakkmir
Titan: Verdungo's Heart, The Doombringer, Goliath
Conqueror: Messerschmidt's Edge, The Cheiftain, Deathwail
Warlord: Goregash, Warlord's Trust, Griswold's Edge
Paladin
Templar: Auyver's Gift, Lenus' Relic, Guardian Angel
Guardian: Gerke's Sanctuary, Lorell's Stone, Horazon's Whip
Justicar: The Revered, The Redeemer, Bane of Acheron
Inquisitor: Goldstrike Fletch, Last Rites, Aemyr's Order
Druid
Destructionist : Hexfire, Pompeii's Wrath, Madayr
Shaman: Twig of Yggdrasil, Blackfur, Nokozan Relic
Cerberus: Steelhorn, Doomfang, Lew's Thirst
Hierophant: Stargazer, Gromhel's Grasp, Skystrike
Sorceress
Arcanist: Edyrem Artifice, Glitterblade, Eger's Dowser
Mage: Blackoak, Spectral Shard, Kira's Guardian
Clairvoyant: Rune Barrier, Visceratuant, Mang Song's Lesson
Cryomancer: Witch's Harp, The Eye of Etlich, Furi-Zu Kyanon
Necromancer
Occultist: Mendeln's Nascency, Dark Whispers, Lidless Wall
Diabolist: Greyform, Horror Hem, Sankekur's Jaw
Warlock: Warlock's Ward, Blackhand Key, Hand of King Leoric
Plaguelord: Ichorstring, Venom Ward, Rotting Face
Amazon
Matriarch: Lance of Iridia, Lycander's Aim, Valkyrie Wing
Huntress: Faunscope, The Cat's Eye, Dahane's Dowry
Ranger: War Traveler, Atma's Scarab, Crescent Moon
Shieldmaiden: Twitchthroe, Thunderstroke, Blackoak
Assassin
Reaper: Bartuc's Cut-throat, Dushara's Hand, Gorefoot
Viper: The Noxious Zephyr, Venom Grip, The Jade Grove
Saboteur: Hunter's Haunches, Wisp Projector, Razortail
Shadow: Fiendslayer, Silkweave, String of Ears
Once obtaining your class-specific base Nephalem's Valor charm, you must sacrifice one out of three of the following relevant Uniques in order to ascend to new powers.
Barbarian
Slayer: Carnage Heart, Deathspade, Rakkmir
Titan: Verdungo's Heart, The Doombringer, Goliath
Conqueror: Messerschmidt's Edge, The Cheiftain, Deathwail
Warlord: Goregash, Warlord's Trust, Griswold's Edge
Paladin
Templar: Auyver's Gift, Lenus' Relic, Guardian Angel
Guardian: Gerke's Sanctuary, Lorell's Stone, Horazon's Whip
Justicar: The Revered, The Redeemer, Bane of Acheron
Inquisitor: Goldstrike Fletch, Last Rites, Aemyr's Order
Druid
Destructionist : Hexfire, Pompeii's Wrath, Madayr
Shaman: Twig of Yggdrasil, Blackfur, Nokozan Relic
Cerberus: Steelhorn, Doomfang, Lew's Thirst
Hierophant: Stargazer, Gromhel's Grasp, Skystrike
Sorceress
Arcanist: Edyrem Artifice, Glitterblade, Eger's Dowser
Mage: Blackoak, Spectral Shard, Kira's Guardian
Clairvoyant: Rune Barrier, Visceratuant, Mang Song's Lesson
Cryomancer: Witch's Harp, The Eye of Etlich, Furi-Zu Kyanon
Necromancer
Occultist: Mendeln's Nascency, Dark Whispers, Lidless Wall
Diabolist: Greyform, Horror Hem, Sankekur's Jaw
Warlock: Warlock's Ward, Blackhand Key, Hand of King Leoric
Plaguelord: Ichorstring, Venom Ward, Rotting Face
Amazon
Matriarch: Lance of Iridia, Lycander's Aim, Valkyrie Wing
Huntress: Faunscope, The Cat's Eye, Dahane's Dowry
Ranger: War Traveler, Atma's Scarab, Crescent Moon
Shieldmaiden: Twitchthroe, Thunderstroke, Blackoak
Assassin
Reaper: Bartuc's Cut-throat, Dushara's Hand, Gorefoot
Viper: The Noxious Zephyr, Venom Grip, The Jade Grove
Saboteur: Hunter's Haunches, Wisp Projector, Razortail
Shadow: Fiendslayer, Silkweave, String of Ears
And result will be something like this: