Thanks for the advice. I meanwhile have gotten to 500k def. Mostly everything maxed out now. Did veteran eyes/tokens and already some BRC quests (amazons are still a beach).
I am also re-equipping my gear. Able to farm most of T and TTran is doable, it's just very hard. Must admit it got better when I got to 500K def. My keyboard skills are pretty good. I have set the keys in a smart way so I only need to press the right fingers, being a piano player helps
All gear is T6, maxed out def on them, dmg, ar etc on unique T6 Valaska. Helm is the highest def model of a barb helm with lucky etc.
Later this evening I will try the first charms on Dest, very curious about gameplay with the ubers
I do feel like it skillswitching is more 'difficult' to time right as there seems to be some kind of inbuilt latency with skillswitching and activating that you don't have in sp.