Hi and welcome.
As Rishab said, please give us all the information you can so we may be able to better help you.
Based on the few information you gave us I'd say first of all make sure your graphics drivers are up to date, that never hurts.
Then, you can try using DDraw display option, it's usually the fastest.
If you want to use Glide, please configure it in the following way:
- under "settings" panel: select only the checkboxes labeled "window-mode", "keep aspect ratio" and "centered". The game usually works better in window mode. Make sure VSYNC is disabled, set the fps limit to 58.8 and static size to "no".
- under "renderer" panel: select the most texture memory that doesn't exceed your video card memory (max is 108MB) and set buffer-texture-size to 1024x1024, select 32-bit and disable bilinear filtering, then quit glide configuration
- back in d2se window, check "-ns disable Sound". This disables in-game sound but improves performance by quite a big margin.