Your Nephalim runeword can have higher ED if you put orbs before making runeword. I think you already know that because you orbed your armor before putting Ith runes, but if you didn't then get another 150% ED, or go with total character def if you want.
Also I was struggling hardcore this ladder, and found that it became a lot more bearable with resists. I'm not talking about 75, I had 73 light resist and died to storm shamans in Nihilithak's area in a second or two at 10kHP. Put witchhunter hood on and pgems in gear and now have 91/93/91/95 and they don't even hurt me through tainted blood regen, the difference is massive.
Edit: just re-read your post and saw you mention you're dying in uberquests, yeah it's a lot harder for some of them this season.